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accolade  Une formation par la recherche

 

La formation par la recherche est essentielle au cours du Magistère de Génétique. A l’issue des 3 années de Magistère (L3, M1 et M2), nos étudiants auront effectué de 14 à 15 mois de stage dans des Instituts nationaux et internationaux de renom.

La meilleure preuve de la qualité des laboratoires d’accueil partenaires du Magistère est la liste des publications générées par nos étudiants lors de leurs stages de L3 et/ou de M1......

 

2018

  • Celia Bosso-Lefévre (PI : Bruno Reversade) Institute of Medical Biology, A*STAR, Singapore. RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefèvre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Başaran S, Yücel EB, Tan TT, Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H, Reversade B. Nature . 2018 May ;557(7706):564-569.
  • Jérémy Choin (PI : Martin Sikora & Eske Willerslev) Centre for GeoGenetics, Natural History Museum, University of Copenhagen, Copenhagen, Denmark. The first horse herders and the impact of early Bronze Age steppe expansions into Asia. De Barros Damgaard P, Martiniano R, Kamm J, Moreno-Mayar JV, Kroonen G, Peyrot M, Barjamovic G, Rasmussen S, Zacho C, Baimukhanov N, Zaibert V, Merz V, Biddanda A, Merz I, Loman V, Evdokimov V, Usmanova E, Hemphill B, Seguin-Orlando A, Yediay FE, Ullah I, Sjögren KG, Iversen KH, Choin J, de la Fuente C, Ilardo M, Schroeder H, Moiseyev V, Gromov A, Polyakov A, Omura S, Senyurt SY, Ahmad H, McKenzie C, Margaryan A, Hameed A, Samad A, Gul N, Khokhar MH, Goriunova OI, Bazaliiskii VI, Novembre J, Weber AW, Orlando L, Allentoft ME, Nielsen R, Kristiansen K, Sikora M, Outram AK, Durbin R, Willerslev E. Science . 2018 Jun 29 ;360(6396).
  • François Muratet (PI : Joseph Buxbaum) Icahn School of Medicine at Mount Sinai, New York, NY. Delineation of the genetic and clinical spectrum of Phelan-McDermid syndrome caused by SHANK3 point mutations. De Rubeis S, Siper PM, Durkin A, Weissman J, Muratet F, Halpern D, Trelles MDP, Frank Y, Lozano R, Wang AT, Holder JL Jr, Betancur C, Buxbaum JD, Kolevzon A. Mol Autism . 2018 Apr 27 ;9:31.
  • Alexandre Fagnan (PI : Mark Hatley) St. Jude Children’s Research Hospital, Memphis, TN, USA. PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma. Hanna JA, Garcia MR, Lardennois A, Leavey PJ, Maglic D, Fagnan A, Go JC, Roach J, Wang YD, Finkelstein D, Hatley ME. Oncogene . 2018 Apr ;37(15):1991-2007.
  • Marie Bordas (PI : Shannon McKinney-Freeman) St. Jude Children’s Research Hospital, Memphis, TN. Nfix Promotes Survival of Immature Hematopoietic Cells via Regulation of c-Mpl. Hall T, Walker M, Ganuza M, Holmfeldt P, Bordas M, Kang G, Bi W, Palmer LE, Finkelstein D, McKinney-Freeman S. Stem Cells . 2018 Jun ;36(6):943-950.
  • Maeva Langouët & Clémence Dupont (PI : Marc Lalande) University of Connecticut. Zinc finger protein 274 regulates imprinted expression of transcripts in Prader-Willi syndrome neurons. Langouët M, Glatt-Deeley HR, Chung MS, Dupont-Thibert CM, Mathieux E, Banda, EC, Stoddard CE, Crandall L, Lalande M.  Hum Mol Genet . 2018 Feb 1 ;27(3):505-515.

 

2017

  • Renaud Pourpre (PI : Kyle Miller) Department of Molecular Biosciences, The University of Texas at Austin, TX, USA. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM.  Genes Dev . 2017 Feb 1 ;31(3):260-274.
  • Xiao Lu (Randall Johnson) Dept of Physiology, Development & Neuroscience, Univ Cambridge, UK. Modelling pulmonary microthrombosis coupled to metastasis : distinct effects of thrombogenesis on tumorigenesis. Colin E. Evans, Asis Palazon, Jingwei Sim, Petros A. Tyrakis, Alice Prodger, Xiao Lu, Saria Chan, Pär-Ola Bendahl, Mattias Belting, Love Von Euler, Helene Rundqvist, Randall S. Johnson, Cristina Branco, Biology Open . 2017, doi : 10.1242/bio.024653, Published By The Company of Biologists Ltd, 2017
  • Urielle François (PI : Lynda Erskine) The Institute of Medical Sciences, University of Aberdeen, UK. VEGF-A and Neuropilin 1(NRP1) shape axon projections in developing CNS via dual roles in neurons & blood vessels. Lynda Erskine, Urielle Francois, Laura Denti, Andy Joyce, Miguel Tillo, Freyja Bruce, Neil Vargesson, and Christiana Ruhrberg Development . 2017 Jul 1 ;144(13) : 2504-2516.
  • Coralie Cazin (PI : Erika Bach), New York University School of Medicine, NY, USA. Neutral Competition for Drosophila Follicle and Cyst Stem Cell Niches Requires Vesicle Trafficking Cook MS, Cazin C, Amoyel M, Yamamoto S, Bach E, Nystul T. Genetics . 2017 Jul ;206(3):1417-1428.
  • Ilan Theurillat (PI : Martine F. Roussel) St. Jude Children’s Research Hospital, Memphis, TN, USA. Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma Vo BT, Li C, Morgan MA, Theurillat I, Finkelstein D, Wright S, Hyle J, Smith SMC, Fan Y, Wang YD, Wu G, Orr BA, Northcott PA, Shilatifard A, Sherr CJ, Roussel MF. Cell Rep . 2017 Mar 21 ;18(12):2907-2917.
  • Manon Rivagorda (PI : Pleasantine Mill) MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, UK. PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. Hall EA, Nahorski MS, Murray LM, Shaheen R, Perkins E, Dissanayake KN, Kristaryanto Y, Jones RA, Vogt J, Rivagorda M, Handley MT, Mali GR, Quidwai T, Soares DC, Keighren MA, McKie L, Mort RL, Gammoh N, Garcia-Munoz A, Davey T, Vermeren M, Walsh D, Budd P, Aligianis IA, Faqeih E, Quigley AJ, Jackson IJ, Kulathu Y, Jackson M, Ribchester RR, von Kriegsheim A, Alkuraya FS, Woods CG, Maher ER, Mill P. Am J Hum Genet . 2017 May 4 ;100(5):706-724.
  • Geoffrey Pires (PI : Thomas Wisniewski) New York University School of Medicine, New York, NY. Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer’s disease. Drummond E, Nayak S, Faustin A, Pires G, Hickman RA, Askenazi M, Cohen M, Haldiman T, Kim C, Han X, Shao Y, Safar JG, Ueberheide B, Wisniewski T. Acta Neuropathol . 2017 Jun ;133(6):933-954.
  • Yetki Aslan (PI : Aaron Zorn) Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA. High-efficiency non-mosaic CRISPR-mediated knock-in and indel mutation in F0 Xenopus. Aslan Y, Tadjuidje E, Zorn AM, Cha SW. Development . 2017 Aug 1 ;144(15):2852-2858.
  • François Muratet (PI : Joseph Buxbaum) Icahn School of Medicine at Mount Sinai, New York, NY. Prospective investigation of FOXP1 syndrome. Siper PM, De Rubeis S, Trelles MDP, Durkin A, Di Marino D, Muratet F, Frank Y, Lozano R, Eichler EE, Kelly M, Beighley J, Gerdts J, Wallace AS, Mefford HC, Bernier RA, Kolevzon A, Buxbaum JD. Mol Autism . 2017 Oct 24 ; 8:57.
  • Camille Bonnet (PI : Christelle Golzio) Dept of psychiatry & behavioural sciences, Duke University, Durham, NC. The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs. Loviglio MN, Arbogast T, Jønch AE, Collins SC, Popadin K, Bonnet CS, Giannuzzi G, Maillard AM, Jacquemont S ; 16p11.2 Consortium, Yalcin B, Katsanis N, Golzio C, Reymond A. Am J Hum Genet . 2017 Oct 5 ;101(4):564-577.
  • Nadège Minoungou (PI : Steve Hahn) Fred Hutchinson Cancer Research Center, Seattle, WA. SAGA Is a General Cofactor for RNA Polymerase II Transcription Baptista T, Grünberg S, Minoungou N, Koster MJE, Timmers HTM, Hahn S, Devys D, Tora L. Mol Cell . 2017 Oct 5 ;68(1):130-143
  • Fanny Roth (PI : Young-Goo Han) St. Jude Children’s Research Hospital, Memphis, TN. mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma Wu CC, Hou S, Orr BA, Kuo BR, Youn YH, Ong T, Roth F, Eberhart CG, Robinson, GW, Solecki DJ, Taketo MM, Gilbertson RJ, Roussel MF, Han YG Dev Cell . 2017 Dec 18 ;43(6):673-688

2016

  • Kenzo Hillion (PI : Erika Bach) New York University School of Medicine, NY, USA. Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues. Amoyel M, Hillion KH, Margolis SR, Bach EA. Development . 2016 Sep 15. pii : dev.139782.
  • Alice Abelanet (PI : Randall Johnson) Dept of Physiology, Development & Neuroscience, Univ Cambridge, UK. S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate. Tyrakis PA, Palazon A, Macias D, Lee KL, Phan AT, Veliça P,You J, Chia GS, Sim J, Doedens A, Abelanet A, Evans CE, Griffiths JR, Poellinger L, Goldrath AW, Johnson RS. Nature . 2016 Dec 8 ;540(7632):236-241.
  • David Leroy (PI : Søren Nørby) Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Prevalence and Genetics of Leber Hereditary Optic Neuropathy in the Danish Population. Rosenberg T, Nørby S, Schwartz M, Saillard J, Magalhães PJ, Leroy D, Kann EC, Duno M.  Invest Ophthalmol Vis Sci . 2016 Mar ;57(3):1370-5.
  • Ketty Kessler (PI : David Solecki) St. Jude Children’s Research Hospital, Memphis, TN. Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition. Singh S, Howell D, Trivedi N, Kessler K, Ong T, Rosmaninho P, Raposo AA, Robinson G, Roussel MF, Castro DS, Solecki DJ. Elife . 2016 May 14 ;5. pii : e12717. doi : 10.7554/eLife.12717.
  • Antonin Thiébaut (PI : Paul Goodyer) Montreal Children’s Hospital Research Institute & McGill University, Montreal, Canada. Wilms Tumor Suppressor, WT1, Cooperates with MicroRNA-26a and MicroRNA-101 to Suppress Translation of the Polycomb Protein, EZH2, in Mesenchymal Stem Cells. Akpa MM, Iglesias D, Chu L, Thiébaut A, Jentoft I, Hammond L, Torban E, Goodyer PR. J Biol Chem . 2016 Feb 19 ;291(8):3785-95.
  • Alba Cico & Ludovic Gaut (PI : Shannon McKinney-Freeman) St. Jude Children’s Research Hospital, Memphis, TN. Functional screen identifies regulators of murine hematopoietic stem cell repopulation. Holmfeldt P, Ganuza M, Marathe H, He B, Hall T, Kang G, Moen J, Pardieck J, Saulsberry AC, Cico A, Gaut L, McGoldrick D, Finkelstein D, Tan K, McKinney-Freeman S. J Exp Med . 2016 Mar 7 ;213(3):433-49.
  • Gaelle Hayot (PI : Christelle Golzio), Dept of psychiatry & behavioural sciences, Duke University, Durham, NC. Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia Bolar NA, Golzio C, Živná M, Hayot G, Van Hemelrijk C, Schepers D, Vandeweyer G, Hoischen A, Huyghe JR, Raes A, Matthys E, Sys E, Azou M, Gubler MC, Praet M, Van Camp G, McFadden K, Pediaditakis I, Přistoupilová A, Hodaňová K, Vyleťal P, Hartmannová H, Stránecký V, Hůlková H, Barešová V, Jedličková I, Sovová J, Hnízda A, Kidd K, Bleyer AJ, Spong RS, Vande Walle J, Mortier G, Brunner H, Van Laer L, Kmoch S, Katsanis N, Loeys BL. Am J Hum Genet . 2016 Jul 7 ;99(1):174-87.

2015

  • Julianne Glazer (PI : François Spitz) European Molecular Biology Laboratory, Heidelberg, Germany. A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes. Tsujimura T, Klein FA, Langenfeld K, Glaser J, Huber W, Spitz F. PLoS Genet . 2015 Jan 8 ;11(1):e1004897.
  • Julianne Glazer & Léo Mathias (PI : Moses Chao) New York University School of Medicine, NY, USA. Mariga A, Glaser J, Mathias L, Xu D, Xiao M, Worley P, Ninan I, Chao MV. Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp. Cell Rep . 2015 Dec 1 ;13(9):1747-56.
  • Théo Ribierre (PI : Stefan Feske) New York University School of Medicine, NY, USA. STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection. Desvignes L, Weidinger C, Shaw P, Vaeth M, Ribierre T, Liu M, Fergus T, Kozhaya L, McVoy L, Unutmaz D, Ernst JD, Feske S. J Clin Invest . 2015 Jun ;125(6):2347-62.
  • Marine Dehecq (PI : Steven Hahn) Fred Hutchinson Cancer Research Center, Seattle, USA. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Luo J, Cimermancic P, Viswanath S, Ebmeier CC, Kim B, Dehecq M, Raman V, Greenberg CH, Pellarin R, Sali A, Taatjes DJ, Hahn S, Ranish J. Mol Cell . 2015 Sep 3 ;59(5):794-806.
  • Iris Guerreiro (PI : Rolf W Stottmann) Divisions of Human Genetics & Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, USA. A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia. Saal HM, Prows CA, Guerreiro I, Donlin M, Knudson L, Sund KL, Chang CF, Brugmann SA, Stottmann RW. Hum Mol Genet . 2015 Jun 15 ;24(12):3399-409.
  • Nicolas Levin et Viviane Boilot (PI : Viji M. Draviam) Department of Genetics, University of Cbridge, UK. A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning Predictions Iorio F, Shrestha RL,Levin N, Boilot V, Garnett MJ, Saez-Rodriguez J, Draviam VM PloS One 2015 DOI : 10.1371/journal.pone.0139446

2014

  • Aurélien Palmyre & Anne-Laure Duchemin (PI : Iain Drummond) Department of Medicine, Massachusetts General Hospital, Boston, MA. Collective epithelial migration drives kidney repair after acute injury Palmyre A, Lee J, Ryklin G, Camarata T, Selig MK, Duchemin AL, Nowak P, Arnaout MA, Drummond IA, Vasilyev A. PLoS One . 2014 Jul 10 ;9(7):e101304
  • Elodie Ferreira (PI : Flo Marlow) Albert Einstein College of Medicine, NY. Oocyte polarity requires a Bucky ball-dependent feedback amplification loop. Heim AE, Hartung O, Rothhämel S, Ferreira E, Jenny A, Marlow FL. Development . 2014 Feb ;141(4):842-54.
  • Leila Ben Merzoug (PI : Martine F. Roussel) St. Jude Children’s Research Hospital, Memphis, TN, USA. Role of the miR-17∼92 cluster family in cerebellar and medulloblastoma development. Zindy F, Kawauchi D, Lee Y, Ayrault O, Ben Merzoug L, McKinnon PJ, Ventura A, Roussel MF. Biol Open . 2014 Jun 13 ;3(7):597-605.
  • Maxence Cornille (PIs : Wa Xian & Frank Mckeon) Jackson Laboratory for Genomic Medicine, University of Connecticut, USA. The PAX2-null immunophenotype defines multiple lineages with common expression signatures in benign and neoplastic oviductal epithelium. Ning G, Bijron JG, Yamamoto Y, Wang X, Howitt BE, Herfs M, Yang E, Hong Y, Cornille M, Wu L, Hanamornroongruang S, McKeon FD, Crum CP, Xian W. J Pathol . 2014 Dec ; 234(4):478-87.
  • Laure Bihannic (PI : Martine F. Roussel) St. Jude Children’s Research Hospital, Memphis, TN, USA. Pemetrexed and gemcitabine as combination therapy for the treatment of group3 medulloblastoma. Morfouace M, Shelat A, Jacus M, Freeman BB 3rd, Turner D, Robinson S, Zindy F, Wang YD, Finkelstein D, Ayrault O, Bihannic L, Puget S, Li XN, Olson JM, Robinson GW, Guy RK, Stewart CF, Gajjar A, Roussel MF. Cancer Cell . 2014 Apr 14 ;25(4):516-29.
  • Fanny Guez (PI : Beatriz Sosa-Pineda) St. Jude Children’s Research Hospital, Memphis, TN, USA. Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development . 2014 Feb ;141(3):538-47.
  • Anne Lenoir (PI : Jian Zuo) St. Jude Children’s Research Hospital, Memphis, TN, USA. Cox BC, Chai R, Lenoir A, Liu Z, Zhang L, Nguyen DH, Chalasani K, Steigelman KA, Fang J, Cheng AG, Zuo J. Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo. Development . 2014 Feb ;141(4):816-29.
  • Marie Mortreux & Maud Wurmser (PI : Ralph Marcucio) UCSF. Abou-Khalil R, Yang F, Mortreux M, Lieu S, Yu YY, Wurmser M, Pereira C, Relaix F, Miclau T, Marcucio RS, Colnot C. Delayed bone regeneration is linked to chronic inflammation in murine muscular dystrophy. J Bone Miner Res . 2014 Feb ;29(2):304-15.
  • Sébastien Lofek-Czubek (PI : Saghi Ghaffari) Mt. Sinai School of Medicine, New York. Rimmelé P, Lofek-Czubek S, Ghaffari S. Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity. Am J Hematol . 2014 Aug 28. doi : 10.1002/ajh.23837. [Epub ahead of print] PubMed PMID : 25163926.
  • Sandrine Chapuis & Julien Fregeac (PI : Feliksas Bukauskas) Albert Einstein College of Medicine, New York. Palacios-Prado N, Chapuis S, Panjkovich A, Fregeac J, Nagy JI, Bukauskas FF. Molecular determinants of magnesium-dependent synaptic plasticity at electrical synapses formed by connexin36. Nat Commun . 2014 Aug 19 ;5:4667. doi:10.1038/ncomms5667.
  • Xiao Lu (PI : Randall Johnson) Dept. Physiology, Development, and Neuroscience, Cambridge University, UK. Evans CE, Wadoodi A, Humphries J, Lu X, Grover SP, Saha P, Smith A. Local accumulation of hypoxia-inducible factor 2 alpha during venous thrombus resolution. Thrombosis Research . 2014, 134, 757-60.

2013

  • Julien Fregeac (PI : Feliksas Bukauskas) Albert Einstein College of Medicine, New York. Lübkemeier I, Andrié R, Lickfett L, Bosen F, Stöckigt F, Dobrowolski R, Draffehn AM, Fregeac J, Schultze JL, Bukauskas FF, Schrickel JW, Willecke K. The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice. J Mol Cell Cardiol . 2013 Dec ;65:19-32. doi:10.1016/j.yjmcc.2013.09.008.
  • Sandrine Chapuis (PI : Feliksas Bukauskas) Albert Einstein College of Medicine, New York. Intracellular Magnesium-Dependent Modulation of Gap Junction Channels Formed by Neuronal Connexin 36. Palacios-Prado, N., Hoge, G., Marandykina, A. Rimkute, L., Chapuis, S., Paulauskas, N., Skeberdis, V.A., O’Brien, J., Pereda, A.E., Bennett, M.V.L., Bukauskas, F.F. J. of Neuroscience . 2013 Mar 13 ;33(11):4741-53.
  • Hadjadj Djihad (PI : Nada Jabado) McGill University, Montréal, Canada. Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas Fontebasso AM, Schwartzentruber J, Khuong-Quang DA, Liu XY, Sturm D, Korshunov A, Jones DT, Witt H, Kool M, Albrecht S, Fleming A, Hadjadj D, Busche S, Lepage P, Montpetit A, Staffa A, Gerges N, Zakrzewska M, Zakrzewski K, Liberski PP, Hauser P, Garami M, Klekner A, Bognar L, Zadeh G, Faury D, Pfister SM, Jabado N, Majewski J. Acta Neuropathol 2013 May ;125(5):659-69.
  • Clémence Claussin, Juliette Bertrand, Amandine Masson (PI : Malcolm Leissring), Dept of Neuroscience, Mayo Clinic, Jacksonville, Florida. Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. Abdul-Hay SO, Lane AL, Caulfield TR, Claussin C, Bertrand J, Masson A, Choudhry S, Fauq AH, Maharvi GM, Leissring MA. J Med Chem . 2013 Mar 28 ;56(6):2246-55.
  • Maximilien Evrard (PI : Alessandra Mortellaro), Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore. The NLRP3 inflammasome links complement-mediated inflammation and IL-1beta release. Laudisi F, Spreafico R, Evrard M, Hughes TR, Mandriani B, Kandasamy M, Morgan BP, Sivasankar B, Mortellaro A. J. Immunol. 2013 Aug 1 ;191(3):1006-10.
  • Amandine Molliex (PI : Paul Taylor) Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, USA. VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Kim NC, Tresse E, Kolaitis RM, Molliex A, Thomas RE, Alami NH, Wang B, Joshi A, Smith RB, Ritson GP, Winborn BJ, Moore J, Lee JY, Yao TP, Pallanck L, Kundu M, Taylor JP. Neuron 2013 Apr 10 ;78(1):65-80.
  • Amandine Molliex (PI : Paul Taylor) Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, USA. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP. Nature 2013 Mar 28 ;495(7442):467-73.
  • Jeremy Magescas (PI : Paul Lasko) Department of Biology, McGill University, Montreal, Canada. Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster. Hernández G, Miron M, Han H, Liu N, Magescas J, Tettweiler G, Frank F, Siddiqui N, Sonenberg N, Lasko P Mol Cell Biol. 2013 Aug ;33(15):2854-64.
  • Delphine Theodorou (PI : Joshua Dubnau) Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. Activation of transposable elements during aging and neuronal decline in Drosophila. Li W, Prazak L, Chatterjee N, Grüninger S, Krug L, Theodorou D, Dubnau J. Nat Neurosci. 2013 May ;16(5):529-31. doi : 10.1038/nn.3368. Epub 2013 Apr 7.

2012

  • Antoine Campagne (PI : Antoine Karoub) Beth Israel Deaconess Medical Center, Harvard Medical School. Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. El-Haibi CP, Bell GW, Zhang J, Collmann AY, Wood D, Scherber CM, Csizmadia E, Mariani O, Zhu C, Campagne A, Toner M, Bhatia SN, Irimia D, Vincent-Salomon A, Karnoub AE Proc. Natl. Acad. Sci. USA 2012 ;109(43):17460-5.
  • Laura Daroles (PI : Jesus Torres-Vásques) Skirball Institute, New York University. In parallel interconnectivity of the dorsal longitudinal anastomotic vessels requires both VEGF signaling and circulatory flow. Zygmunt T, Trzaska S, Edelstein L, Walls J, Rajamani S, Gale N, Daroles L, Ramírez C, Ulrich F, Torres-Vázquez J. J. Cell Sci. 2012 Aug 16. [Epub ahead of print],
  • Delphine Theodorou (PI : Patrick Varga-Weisz) Babraham Institute, Cambridge UK (L3). SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere establishment in S. cerevisiae Durand-Dubief M, Will WR, Petrini E, Theodorou D, Harris RR, Crawford MR, Paszkiewicz K, Krueger F, Correra RM, Vetter AT, Miller JR, Varga-Weisz P PLoS Genetics (2012) Sep ;8(9):e1002974. doi : 10.1371/journal.pgen.1002974. Epub 2012 Sep 27
  • Hadjadj Djihad (PI : Nada Jabado) McGill University, Montréal, Canada. Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Liu XY, Gerges N, Korshunov A, Sabha N, Khuong-Quang DA, Fontebasso AM, Fleming A, Hadjadj D, Schwartzentruber J, Majewski J, Dong Z, Siegel P, Albrecht S, Croul S, Jones DT, Kool M, Tonjes M, Reifenberger G, Faury D, Zadeh G, Pfister S, Jabado N. Acta Neuropathol . 2012 ; 124(5):615-25.
  • Aurélien Palmyre (PI : Jacques Genest) McGill University, Montréal, Canada. Iatan I, Palmyre A, Alrasheed S, Ruel I, Genest J. Genetics of Cholesterol Efflux. Current Atherosclerosis Reports. 2012 ; 14(3) : 235-246
  • Jean-Philippe Grossier (PI : Julian M Ketley) University of Leicester, UK. Phase variable genes of Campylobacter jejuni exhibit high mutation rates and specific mutational patterns but mutability is not the major determinant of population structure during host colonization. Bayliss CD, Bidmos FA, Anjum A, Manchev VT, Richards RL, Grossier JP, Wooldridge KG, Ketley JM, Barrow PA, Jones MA, Tretyakov MV. Nucleic Acids Res . 2012 ; 40(13):5876-89.
  • Guillaume Oller (PI : Florent Ginhoux) Singapore Immunology Network, A*STAR. Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages. Hoeffel G, Wang Y, Greter M, See P, Teo P, Malleret B, Leboeuf M, Low D, Oller G, Almeida F, Choy SH, Grisotto M, Renia L, Conway SJ, Stanley ER, Chan JK, Ng LG, Samokhvalov IM, Merad M, Ginhoux F. J Exp Med. 2012 ;209(6):1167-81.
  • Muriel Desbois (PI : Hannes Bülow) Albert Einstein College of Medicine, New York. Direct visualization of specifically modified extracellular glycans in living animals. Attreed M, Desbois M, van Kuppevelt TH, Bülow HE. Nature Methods 2012 ; 9 : 477–479.
  • Jacques Marquay Markiewicz (PI : Pauline Schaap) University of Dundee, Scotland, UK. Evolution of self-organisation in Dictyostelia by adaptation of a non-selective phosphodiesterase and a matrix component for regulated cAMP degradation. Kawabe Y, Weening K, Marquay Markiewicz J, Rozen DE, Schaap P. Development. 2012 ; 139:1336-45
  • Laura Lauden (PI : Sandra Wolin) Dept. Of Cell Biology, Yale University, New Haven CT, USA. Yeast Gis2 and its human ortholog CNBP are novel components of stress-induced RNP granules. Rojas M, Farr GW, Fernandez CF, Lauden L, McCormack JC, Wolin SL. PLoS One. 2012 ;7(12):e52824. doi : 10.1371/journal.pone.0052824. Epub 2012 Dec 21.

2011

  • Jordan Blondelle (PI : Jesús Torres-Vásquez) New York University School of Medicine/Skirball Institute. Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1. Zygmunt T, Gay CM, Blondelle J, Singh MK, Flaherty KM, Means PC, Herwig L, Krudewig A, Belting HG, Affolter M, Epstein JA, Torres-Vázquez J. Dev Cell. 2011 ; 21(2):301-14.
  • Julie Tordo (PI : Grigori Enikolopov) Cold Spring Harbor Laboratory. Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Encinas JM, Michurina TV, Peunova N, Park JH, Tordo J, Peterson DA, Fishell G, Koulakov A, Enikolopov G. Cell Stem Cell. 2011 ; 8(5):566-79.
  • Dorian Obino (PIs : Catherine Alcaide-Loridan & Frederique Deshayes) Institut Jacques Monod, Paris. Junctional Adhesion Molecules are required for melanoma transendothelial migration. Ghislin S, Obino D , Middendorp S, Boggetto N, Alcaide-Loridan C, Deshayes F. Pigment Cell & Melanoma Research 2011 ; 24(3):504-11
  • Carole Nasrallah (PI : Eric Thompson) Sars International Centre for Marine Molecular Biology, Norway. Histone variant innovation in a rapidly evolving chordate lineage. Moosmann A, Campsteijn C, Jansen PW, Nasrallah C, Raasholm M, Stunnenberg HG, Thompson EM. BMC Evol Biol. 2011 ; 11:208.
  • Lucie Coillard (PI : Archibald Perkins) University of Rochester Medical Center. PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Zhang Y, Stehling-Sun S, Lezon-Geyda K, Juneja SC, Coillard L, Chatterjee G, Wuertzer CA, Camargo F, Perkins AS. Blood 2011 ; 118:3853-61.
  • Elodie Pauwels (PI : P Gros) University of Montreal. Contribution of VANGL2 mutations to isolated neural tube defects. Kibar Z, Salem S, Bosoi CM, Pauwels E, De Marco P, Merello E, Bassuk AG, Capra V, Gros P. Clin Genet. 2011 ; 80(1):76-82.
  • Géraldine Sicot (PI : Archibald Perkins) University of Rochester Medical Center. Targeting a DNA binding motif of the EVI1 protein by pyrrole-imidazole polyamide. Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer C, Lezon-Geyda K, Wheeler J, Harki D, Muzikar K, Stolper D, Dervan P, Perkins A. Biochemistry 2011 ; 50:10431-10441.

2010

  • Charlotte Leblanc (PI : Greg Suh) New York University school of Medicine/Skirball Institute. Acid sensing by the Drosophila olfactory system. Ai M, Min S, Grosjean Y, Leblanc C, Bell R, Benton R, Suh GS. Nature 2010 ; 468(7324):691-5
  • Lucie Coillard (PI : Roland Baron) Harvard University. Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K, Neff L, Atfi A, Coillard L, Sitara D, Maeda Y, Warming S, Jenkins NA, Copeland NG, Horne WC, Lanske B, Baron R. Dev Cell . 2010 ; 19(4):533-46.
  • Fany Bourgois-Rocha (PI : Marc Lalande) University of Connecticut. Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes. Chamberlain SJ, Chen PF, Ng KY, Bourgois-Rocha F, Lemtiri-Chlieh F, Levine ES, Lalande M.  Proc Natl Acad Sci U S A . 2010 107(41):17668-73.
  • Julie Prudhomme (PI : Randy Johnston) University of Calgary. The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status. Kim M, Williamson CT, Prudhomme J, Bebb DG, Riabowol K, Lee PW, Lees-Miller SP, Mori Y, Rahman MM, McFadden G, Johnston RN. Oncogene . 2010 ; 29(27):3990-6.
  • Ausra Bendoraite (PI : Muneesh Tewari) Fred Hutchinson Cancer Research Center, Seattle. Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer : evidence supporting a mesothelial-to-epithelial transition. Bendoraite A, Knouf EC, Garg KS, Parkin RK, Kroh EM, O’Briant KC, Ventura AP, Godwin AK, Karlan BY, Drescher CW, Urban N, Knudsen BS, Tewari M.  Gynecol Oncol. 2010 ; 116(1):117-25.
  • Pauline Salis & Amine Marouf (PI : Erika Bach) New York University School of Medicine. Chinmo is a Functional Effector of the JAK/STAT Pathway that Regulates Eye Development, Tumor Formation, and Stem Cell Self-Renewal in Drosophila Flaherty MS, Salis P, Evans CJ, Ekas LA, Marouf A, Zavadil J, Banerjee U, Bach EA. Dev Cell. 2010 ; 18(4):556-68.
  • Virginie Lelarge (PI : Stefan Feske) New York University School of Medicine. Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma. Byun M, Abhyankar A, Lelarge V, Plancoulaine S, Palanduz A, Telhan L, Boisson B, Picard C, Dewell S, Zhao C, Jouanguy E, Feske S, Abel L, Casanova JL. J Exp Med. 2010 ; 207(11):2307-12.
  • Marion Pilorge (PI : Joseph Buxbaum) Mount Sinai School of Medicine, New York. A large-scale survey of the novel 15q24 microdeletion syndrome in autism spectrum disorders identifies an atypical deletion that narrows the critical region. McInnes LA, Nakamine A, Pilorge M, Brandt T, Jiménez González P, Fallas M, Manghi ER, Edelmann L, Glessner J, Hakonarson H, Betancur C, Buxbaum JD. Mol Autism. 2010 ; Mar 19 ;1(1):5.
  • Marion Pilorge (PI : Joseph Buxbaum) Mount Sinai School of Medicine, New York. Functional impact of global rare copy number variation in autism spectrum disorders. Pinto D, et al. (among a total of approx. 100 authors). Nature. 2010 ; 466(7304):368-72.
  • Marc Nomaksteinsky (PI : Randall S. Johnson) University of California, San Diego. Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Stockmann C, Kerdiles Y, Nomaksteinsky M, Weidemann A, Takeda N, Doedens A, Torres-Collado AX, Iruela-Arispe L, Nizet V, Johnson RS. Proc Natl Acad Sci U S A. 2010 ; 107(9):4329-34.
  • Elodie Pauwels (PI : P Gros) University of Montreal. Contribution of VANGL2 mutations to isolated neural tube defects. Kibar Z, Salem S, Bosoi CM, Pauwels E, De Marco P, Merello E, Bassuk AG, Capra V, Gros P. Clin Genet. 2010 ; Jul 22. [Epub ahead of print]

 

2009

  • Pauline Gosselin (PI : Joan Brugge) Harvard University. Mutant p53 drives invasion by promoting integrin recycling. Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH. Cell. 2009 ; 139(7):1327-41.
  • Christelle Cabrol (PI : Malcolm Leissring) Mayo Clinic, Jacksonville, Florida. Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening. Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA. PLoS One. 2009 ; 4(4):e5274.
  • Ausra Bendoraite (PI : Muneesh Tewari) Fred Hutchinson Cancer Research Center, Seattle. Quality assessment and data analysis for microRNA expression arrays. Sarkar D, Parkin R, Wyman S, Bendoraite A, Sather C, Delrow J, Godwin AK, Drescher C, Huber W, Gentleman R, Tewari M. Nucleic Acids Res. 2009 ; 37(2):e17.
  • Hugo Bretes (PI : Mario de Bono) Cambridge University. Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans. Persson A, Gross E, Laurent P, Busch KE, Bretes H, de Bono M. Nature. 2009 ; 458(7241):1030-3.
  • Remi Coux (PI : Ruth Lehmann) New York University School of Medicine /Skirball Institute. Temporal and spatial control of germ-plasm RNAs. Rangan P, DeGennaro M, Jaime-Bustamante K, Coux RX, Martinho RG, Lehmann R. Curr Biol. 2009 ; 19(1):72-7.
  • Camilla Pilati (PI : Jessica Zucman-Rossi) INSERM U67 & Univ Paris 7, Institut Français d’hématologie, Paris. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Rebouissou S, Amessou M, Couchy G, Poussin K, Imbeaud S, Pilati C, Izard T, Balabaud C, Bioulac-Sage P, Zucman-Rossi J. Nature 2009 ; 457(7226):200-204.
  • Jean-Luc Tison (PI : Diane Cox), University of Alberta, Edmonton, Canada. A minigene approach for analysis of ATP7B splice variants in patients with Wilson disease. Wilson AM, Schlade-Bartusiak K, Tison JL, Macintyre G, Cox DW. Biochimie. 2009 ; 91(10):1342-5.
  • Sophie Jamet (PI : Hernan Lopez Schier) Centre de Regulacio Genomica, Barcelona. The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish. Gleason MR, Nagiel A, Jamet S, Vologodskaia M, López-Schier H, Hudspeth AJ. Proc Natl Acad Sci U S A. 2009 ; 106(50):21347-52.
  • Stéphanie Devignot (PI : Deborah Dean) Children’s Hospital Oakland Research Institute, Oakland, CA. Predicting phenotype and emerging strains among Chlamydia trachomatis infections. Dean D, Bruno WJ, Wan R, Gomes JP, Devignot S, Mehari T, de Vries HJ, Morré SA, Myers G, Read TD, Spratt BG. Emerg Infect Dis. 2009 ; 15(9):1385-94.

 

2008

  • Ausra Bendoraite (PI : Muneesh Tewari) Fred Hutchinson Cancer Research Center, Seattle. MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries. Bar M, Wyman SK, Fritz BR, Qi J, Garg KS, Parkin RK, Kroh EM, Bendoraite A, Mitchell PS, Nelson AM, Ruzzo WL, Ware C, Radich JP, Gentleman R, Ruohola-Baker H, Tewari M. Stem Cells. 2008 ; 26(10):2496-505.
  • Ausra Bendoraite (PI : Muneesh Tewari) Fred Hutchinson Cancer Research Center, Seattle. Derivation, characterization, and in vitro differentiation of canine embryonic stem cells. Hayes B, Fagerlie SR, Ramakrishnan A, Baran S, Harkey M, Graf L, Bar M, Bendoraite A, Tewari M, Torok-Storb B. Stem Cells. 2008 ; 26(2):465-73.
  • Laura Gainche (PI : Xandra Breakefield) Harvard University. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, Curry WT Jr, Carter BS, Krichevsky AM, Breakefield XO. Nat Cell Biol. 2008 ; 10(12) : 1470-6.
  • Flavia Guillem (PI : Peter Warburton) Mount Sinai School of Medicine, New York. Analysis of the largest tandemly repeated DNA families in the human genome. Warburton PE, Hasson D, Guillem F, Lescale C, Jin X, Abrusan G. BMC Genomics. 2008 ; 9:533.
  • Michel Wassef (PI : Jessica Treisman) NYU School of Medicine/Skirball Institute. Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor. G.I. Miura, J.-Y. Roignant, M. Wassef and J.E. Treisman. Development 2008 ; 135 : 1913-1922.
  • Fabien Duveau (PI : Jessica Treisman) NYU School of Medicine/Skirball Institute. Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. I. Carrera, F. Janody, N. Leeds, F. Duveau and J.E. Treisman. Proc. Natl. Acad. Sci. USA 2008 ; 105 : 6644-6649.
  • Marie Néant-Fery (PI : Malcolm Leissring) Scripps Research Institute, Florida. Molecular basis for the thiol sensitivity of insulin-degrading enzyme. Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA. Proc Natl Acad Sci U S A. 2008 ; 105(28):9582-7.
  • Isabelle Martins (PI : Beatriz Sosa-Pineda) St. Jude Children’s Research Hospital, Memphis. Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum. Wang Q, Elghazi L, Martin S, Martins I, Srinivasan RS, Geng X, Sleeman M, Collombat P, Houghton J, Sosa-Pineda B. Dev Dyn. 2008 ; 237(1):51-61.

 

2007

  • Sandra Pineau (PI : D Rubinsztein) University of Cambridge. Small molecules enhance autophagy and reduce toxicity in Huntington’s disease models. Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O’Kane CJ, Schreiber SL, Rubinsztein DC. Nat Chem Biol. 2007 3(6):331-8.
  • Lydie Morel (PI : Alexis Brice) INSERM U679 & Univ Paris 6, Hôpital Pitié-Salpêtrière, Paris. A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes. Latouche M, Lasbleiz C, Martin E, Monnier V, Debeir T, Mouatt-Prigent A, Muriel MP, Morel L, Ruberg M, Brice A, Stevanin G, Tricoire H. 
 J Neurosci 2007 ; 27(10):2483-92.
  • Marie Néant-Fery (PI : Malcolm Leissring) Scripps Research Institute, Florida. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ. J Biol Chem. 2007 ;282(35):25453-63.

 

2006

  • Sophie Hamel (PI : Jessica Treisman) NYU School of Medicine/Skirball Institute. The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway. J.-Y. Roignant, S. Hamel, F. Janody, and J.E. Treisman. Genes Dev. 2006. 20 : 795-806.
  • Michel Trichet (PI : Erich Hoffmann) St. Jude Children’s Research Hospital, Memphis. The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. Salomon R, Franks J, Govorkova EA, Ilyushina NA, Yen HL, Hulse-Post DJ, Humberd J, Trichet M, Rehg JE, Webby RJ, Webster RG, Hoffmann E. J Exp Med. 2006 ; 203(3):689-97.
  • Maryaline Coffre, Antoine De Pauw, Nouara Lhocine (PI : Peter Murray) St. Jude Children’s Research Hospital, Memphis. General nature of the STAT3-activated anti-inflammatory response. El Kasmi KC, Holst J, Coffre M, Mielke L, de Pauw A, Lhocine N, Smith AM, Rutschman R, Kaushal D, Shen Y, Suda T, Donnelly RP, Myers MG Jr, Alexander W, Vignali DA, Watowich SS, Ernst M, Hilton DJ, Murray PJ. J Immunol. 2006 ; 177(11):7880-8.

 

2005

  • Saul Yogev (PI : Marek Mlodzik) Mount Sinai School of Medicine, New York. The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye. Djiane A, Yogev S, Mlodzik M. Cell. 2005 121(4):621-31.

 

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